Clinical features and their association with death in a large cohort of adult inpatients with COVID-19
Objective: To determine the clinical features and their association with death in a large cohort of adult inpatients with COVID-19. Material and Methods: Retrospective cohort study of patients admitted by COVID-19 to the Almenara General Hospital in Lima, Peru, between March and May 2020. Clinical features on admission were evaluated according to death in bivariate and multivariate Cox regression analyses. Results: A total of 533 patients were included (23% women; 55% over 60 years-old; 27% death). Those who died had significantly higher proportions of patients over 60 years, pre-existing diseases, and severe/critical illness compared to alive patients: 73% vs. 44%, p<0.001; 68% vs. 57%, p=0.021; and 46%/34% vs. 28%/16%, p<0.001, respectively. In
bivariate analyses age over 60 years (uHR 2.49, 95%CI: 1.83-3.39), atrial fibrillation (uHR 2.09, 95%CI: 1.03-4.24) and hypothyroidism (uHR 2.75, 95%CI: 1.02-7.45) were associated with death. While in the multivariate analyses age over 60 years (aHR 2.53, 95%CI: 1.81-3.53), obesity (aHR 2.43, 95%CI: 1.44-4.07), chronic renal disease (aHR 2.65, 95%CI: 1.21-5.82) and hypothyroidism (aHR 4.22, 95%CI: 1.47-12.1) were independently associated with higher risk of death. Conclusions: During the first two months of the epidemic, patients admitted by COVID-19 at the Almenara General Hospital were more frequently older men and had a relevant pre-existing disease burden, as well as severe and critical illness. Mortality was high and was associated with older age, obesity, chronic renal disease, and hypothyroidism.
Derechos de autor 2023 Jaime A. Collins, Ángel A. Altamirano, Nadia C. Delgado, José L. Vargas, Manuel J. Cáceres, Gerson E. Díaz, Enrique A. Hernández, Joshuan J. Barboza, Adrián V. Hernández
Esta obra está bajo licencia internacional Creative Commons Reconocimiento 4.0.